Gö 6976   Click here for help

GtoPdb Ligand ID: 5973

Synonyms: Go 6976 | Go-6976 | Go6976 | Goe 6976
PDB Ligand
Compound class: Synthetic organic
Comment: This compound is an ATP competitive inhibitor of classical type PKC isoenzymes.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 62.75
Molecular weight 378.15
XLogP 4.39
No. Lipinski's rules broken 0
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Canonical SMILES N#CCCn1c2ccccc2c2c1c1c(c3c2CNC3=O)c2c(n1C)cccc2
Isomeric SMILES N#CCCn1c2ccccc2c2c1c1c(c3c2CNC3=O)c2c(n1C)cccc2
InChI InChI=1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)
1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011)
Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.
Nat Biotechnol, 29 (11): 1039-45. [PMID:22037377]
2. Gao Y, Davies SP, Augustin M, Woodward A, Patel UA, Kovelman R, Harvey KJ. (2013)
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Biochem J, 451 (2): 313-28. [PMID:23398362]
3. Gschwendt M, Dieterich S, Rennecke J, Kittstein W, Mueller HJ, Johannes FJ. (1996)
Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes.
FEBS Lett, 392 (2): 77-80. [PMID:8772178]
4. Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H, Marmé D, Schächtele C. (1993)
Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.
J Biol Chem, 268 (13): 9194-7. [PMID:8486620]
5. Ye J, Chen S, Maniatis T. (2011)
Cardiac glycosides are potent inhibitors of interferon-β gene expression.
Nat Chem Biol, 7 (1): 25-33. [PMID:21076398]
6. Yoshida A, Ookura M, Zokumasu K, Ueda T. (2014)
Gö6976, a FLT3 kinase inhibitor, exerts potent cytotoxic activity against acute leukemia via inhibition of survivin and MCL-1.
Biochem Pharmacol, 90 (1): 16-24. [PMID:24735609]