galnon   Click here for help

GtoPdb Ligand ID: 6118

Compound class: Synthetic organic
Comment: Please note that in the article describing its design and discovery galnon is shown as being non-isomeric [3]. This non-isomeric structure is also represented by CID 9961490.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 9
Hydrogen bond donors 4
Rotatable bonds 17
Topological polar surface area 152.76
Molecular weight 678.34
XLogP 7.86
No. Lipinski's rules broken 2
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Canonical SMILES NCCCCC(C(=O)Nc1ccc2c(c1)oc(=O)cc2C)NC(=O)C(NC(=O)OCC1c2ccccc2c2c1cccc2)CC1CCCCC1
Isomeric SMILES NCCCC[C@@H](C(=O)Nc1ccc2c(c1)oc(=O)cc2C)NC(=O)[C@@H](NC(=O)OCC1c2ccccc2c2c1cccc2)CC1CCCCC1
InChI InChI=1S/C40H46N4O6/c1-25-21-37(45)50-36-23-27(18-19-28(25)36)42-38(46)34(17-9-10-20-41)43-39(47)35(22-26-11-3-2-4-12-26)44-40(48)49-24-33-31-15-7-5-13-29(31)30-14-6-8-16-32(30)33/h5-8,13-16,18-19,21,23,26,33-35H,2-4,9-12,17,20,22,24,41H2,1H3,(H,42,46)(H,43,47)(H,44,48)/t34-,35-/m0/s1
1. Bartfai T, Lu X, Badie-Mahdavi H, Barr AM, Mazarati A, Hua XY, Yaksh T, Haberhauer G, Ceide SC, Trembleau L et al.. (2004)
Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests.
Proc Natl Acad Sci USA, 101 (28): 10470-5. [PMID:15240875]
2. Lu X, Lundström L, Langel U, Bartfai T. (2005)
Galanin receptor ligands.
Neuropeptides, 39 (3): 143-6. [PMID:15944002]
3. Sollenberg U, Bartfai T, Langel U. (2005)
Galnon--a low-molecular weight ligand of the galanin receptors.
Neuropeptides, 39 (3): 161-3. [PMID:15944006]