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Synonyms: HT 2157 | HT-2157
Compound class: Synthetic organic
Comment: This compound is represented on ChEMBL by the entry CHEMBL210288 which specified stereochemistry around the double bond.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Konkel MJ, Lagu B, Boteju LW, Jimenez H, Noble S, Walker MW, Chandrasena G, Blackburn TP, Nikam SS, Wright JL et al.. (2006)
3-arylimino-2-indolones are potent and selective galanin GAL3 receptor antagonists.
J Med Chem, 49 (13): 3757-8. [PMID:16789730]
2. Konkel MJ, Packiarajan M, Chen H, Topiwala UP, Jimenez H, Talisman IJ, Coate H, Walker MW. (2006)
Amino substituted analogs of 1-phenyl-3-phenylimino-2-indolones with potent galanin Gal3 receptor binding affinity and improved solubility.
Bioorg Med Chem Lett, 16 (15): 3950-4. [PMID:16730981]
3. Swanson CJ, Blackburn TP, Zhang X, Zheng K, Xu ZQ, Hökfelt T, Wolinsky TD, Konkel MJ, Chen H, Zhong H et al.. (2005)
Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299.
Proc Natl Acad Sci USA, 102 (48): 17489-94. [PMID:16287967]