neuromedin B   Click here for help

GtoPdb Ligand ID: 613

Abbreviated name: NMB
Comment: NMB-10 sequence is identical across human, mouse, rat and pig
Species: Human, Mouse, Rat, Pig
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2D Structure
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Canonical SMILES CSCCC(C(=O)N)NC(=O)C(NC(=O)C(Cc1[nH]cnc1)NC(=O)CNC(=O)C(C(O)C)NC(=O)C(NC(=O)C(Cc1c[nH]c2c1cccc2)NC(=O)C(NC(=O)C(NC(=O)CN)CC(=O)N)CC(C)C)C)Cc1ccccc1
Isomeric SMILES CSCCC(C(=O)N)NC(=O)C(NC(=O)C(Cc1[nH]cnc1)NC(=O)CNC(=O)C(C(O)C)NC(=O)C(NC(=O)C(Cc1c[nH]c2c1cccc2)NC(=O)C(NC(=O)C(NC(=O)CN)CC(=O)N)CC(C)C)C)Cc1ccccc1
InChI InChI=1S/C52H73N15O12S/c1-27(2)17-36(64-51(78)40(21-41(54)69)61-42(70)22-53)48(75)66-38(19-31-23-57-34-14-10-9-13-33(31)34)47(74)60-28(3)46(73)67-44(29(4)68)52(79)58-25-43(71)62-39(20-32-24-56-26-59-32)50(77)65-37(18-30-11-7-6-8-12-30)49(76)63-35(45(55)72)15-16-80-5/h6-14,23-24,26-29,35-40,44,57,68H,15-22,25,53H2,1-5H3,(H2,54,69)(H2,55,72)(H,56,59)(H,58,79)(H,60,74)(H,61,70)(H,62,71)(H,63,76)(H,64,78)(H,65,77)(H,66,75)(H,67,73)
1. Benya RV, Kusui T, Pradhan TK, Battey JF, Jensen RT. (1995)
Expression and characterization of cloned human bombesin receptors.
Mol Pharmacol, 47 (1): 10-20. [PMID:7838118]
2. González N, Mantey SA, Pradhan TK, Sancho V, Moody TW, Coy DH, Jensen RT. (2009)
Characterization of putative GRP- and NMB-receptor antagonist's interaction with human receptors.
Peptides, 30 (8): 1473-86. [PMID:19463875]
3. Jensen RT, Battey JF, Spindel ER, Benya RV. (2008)
International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states.
Pharmacol Rev, 60 (1): 1-42. [PMID:18055507]
4. Ramos-Álvarez I, Moreno P, Mantey SA, Nakamura T, Nuche-Berenguer B, Moody TW, Coy DH, Jensen RT. (2015)
Insights into bombesin receptors and ligands: Highlighting recent advances.
Peptides, 72: 128-44. [PMID:25976083]
5. Ryan RR, Katsuno T, Mantey SA, Pradhan TK, Weber HC, Coy DH, Battey JF, Jensen RT. (1999)
Comparative pharmacology of the nonpeptide neuromedin B receptor antagonist PD 168368.
J Pharmacol Exp Ther, 290 (3): 1202-11. [PMID:10454496]
6. Uehara H, González N, Sancho V, Mantey SA, Nuche-Berenguer B, Pradhan T, Coy DH, Jensen RT. (2011)
Pharmacology and selectivity of various natural and synthetic bombesin related peptide agonists for human and rat bombesin receptors differs.
Peptides, 32 (8): 1685-99. [PMID:21729729]