Compound class:
Endogenous peptide in human, mouse or rat
Comment: IL-27 is an IL-12 family cytokine. It is a heterodimeric cytokine that contains an α and a β subunit and is expressed by activated antigen presenting cells [1]. IL-27 interaction with its receptor complex activates the JAK/STAT and p38 MAPK pathways.
Species: Human
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| References |
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1. Meka RR, Venkatesha SH, Dudics S, Acharya B, Moudgil KD. (2015)
IL-27-induced modulation of autoimmunity and its therapeutic potential. Autoimmun Rev, 14 (12): 1131-41. [PMID:26253381] |
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2. Yoshida H, Hunter CA. (2015)
The immunobiology of interleukin-27. Annu Rev Immunol, 33: 417-43. [PMID:25861977] |
