BIIL 260   Click here for help

GtoPdb Ligand ID: 6154

Synonyms: BIIL-260 | BIIL260
PDB Ligand
Compound class: Synthetic organic
Comment: BIIL 260 is a leukotriene B4 (BLT1) receptor antagonist and is the active metabolite of the prodrug BIIL 284 (amelubant).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 3
Rotatable bonds 9
Topological polar surface area 88.56
Molecular weight 466.23
XLogP 7.79
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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Canonical SMILES Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C
Isomeric SMILES Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C
InChI InChI=1S/C30H30N2O3/c1-30(2,24-8-12-26(33)13-9-24)25-10-16-28(17-11-25)35-20-22-5-3-4-21(18-22)19-34-27-14-6-23(7-15-27)29(31)32/h3-18,33H,19-20H2,1-2H3,(H3,31,32)
InChI Key MBLJFKQACMILLC-UHFFFAOYSA-N
References
1. Birke FW, Meade CJ, Anderskewitz R, Speck GA, Jennewein HM. (2001)
In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B(4) receptor antagonist.
J Pharmacol Exp Ther, 297 (1): 458-66. [PMID:11259574]
2. Díaz-González F, Alten RH, Bensen WG, Brown JP, Sibley JT, Dougados M, Bombardieri S, Durez P, Ortiz P, de-Miquel G et al.. (2007)
Clinical trial of a leucotriene B4 receptor antagonist, BIIL 284, in patients with rheumatoid arthritis.
Ann Rheum Dis, 66 (5): 628-32. [PMID:17170051]