MM54   Click here for help

GtoPdb Ligand ID: 6186

Synonyms: cyclo(1-6)CRPRLC-KH-cyclo(9-14)CRPRLC
Comment: MM54 is an apelin receptor antagonist. It has been to suppress tumour growth and increase survival in an intracranial xenograft mouse model of glioblastoma [1].
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1. Harford-Wright E, Andre-Gregoire G, Jacobs KA, Treps L, Le Gonidec S, Leclair HM, Gonzalez-Diest S, Roux Q, Guillonneau F, Loussouarn D et al.. (2017)
Pharmacological targeting of apelin impairs glioblastoma growth.
Brain, 140 (11): 2939-2954. [PMID:29053791]
2. Macaluso NJ, Pitkin SL, Maguire JJ, Davenport AP, Glen RC. (2011)
Discovery of a competitive apelin receptor (APJ) antagonist.
ChemMedChem, 6 (6): 1017-23. [PMID:21560248]