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azithromycin is an approved drug (FDA & UK (1991))
Compound class: Synthetic organic
Comment: Azithromycin is a macrolide antibiotic with broad-spectrum activity against Gram-positive and atypical bacteria. The compound also has antimalarial activity.
Azithromycin is one of the watch group antibacterials in the the World Health Organisation's List of Essential Medicines (link provided in the Classification table below).
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Broad J, Sanger GJ. (2013)
The antibiotic azithromycin is a motilin receptor agonist in human stomach: comparison with erythromycin.
Br J Pharmacol, 168 (8): 1859-67. [PMID:23190027]
2. Dahl EL, Rosenthal PJ. (2007)
Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast.
Antimicrob Agents Chemother, 51 (10): 3485-90. [PMID:17698630]
3. van Eijk AM, Terlouw DJ. (2011)
Azithromycin for treating uncomplicated malaria.
Cochrane Database Syst Rev, (2): CD006688. [PMID:21328286]