sulforaphane   Click here for help

GtoPdb Ligand ID: 6569

Compound class: Natural product or derivative
Comment: Found in cruciferous vegetables such as brocolli. It has potential chemopreventive [1], anti-cancer [4] and neuroprotective actions [3]. It may act as a quinone reductase inducer [2].
2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 80.73
Molecular weight 177.03
XLogP 1.18
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

✖
Canonical SMILES S=C=NCCCCS(=O)C
Isomeric SMILES S=C=NCCCCS(=O)C
InChI InChI=1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3
InChI Key SUVMJBTUFCVSAD-UHFFFAOYSA-N
References
1. Grabacka MM, Gawin M, Pierzchalska M. (2014)
Phytochemical modulators of mitochondria: the search for chemopreventive agents and supportive therapeutics.
Pharmaceuticals (Basel), 7 (9): 913-42. [PMID:25192192]
2. Pawlus AD, Su BN, Keller WJ, Kinghorn AD. (2005)
An anthraquinone with potent quinone reductase-inducing activity and other constituents of the fruits of Morinda citrifolia (noni).
J Nat Prod, 68 (12): 1720-2. [PMID:16378361]
3. Tarozzi A, Angeloni C, Malaguti M, Morroni F, Hrelia S, Hrelia P. (2013)
Sulforaphane as a potential protective phytochemical against neurodegenerative diseases.
Oxid Med Cell Longev, 2013: 415078. [PMID:23983898]
4. Zhang Y, Talalay P, Cho CG, Posner GH. (1992)
A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.
Proc Natl Acad Sci USA, 89 (6): 2399-403. [PMID:1549603]