echistatin   Click here for help

GtoPdb Ligand ID: 6594

Comment: Echistatin is a disintegrin derived from the venom of several viper species. The reference from which our biological activity data is from does not specify the exact form of echistatin used in their experiments. The sequence shown here represents the α1 isoform. Echistatin acts as an αVβ3 integrin and glycoprotein IIb/IIIa (αIIbβ3) inhibitor. Echistatin inhibits platelet aggregation [1], i.e. it has an anti-coagulant effect.
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1. Garsky VM, Lumma PK, Freidinger RM, Pitzenberger SM, Randall WC, Veber DF, Gould RJ, Friedman PA. (1989)
Chemical synthesis of echistatin, a potent inhibitor of platelet aggregation from Echis carinatus: synthesis and biological activity of selected analogs.
Proc Natl Acad Sci USA, 86 (11): 4022-6. [PMID:2726764]
2. Lee Y, Kang DK, Chang SI, Han MH, Kang IC. (2004)
High-throughput screening of novel peptide inhibitors of an integrin receptor from the hexapeptide library by using a protein microarray chip.
J Biomol Screen, 9 (8): 687-94. [PMID:15634795]