echistatin   Click here for help

GtoPdb Ligand ID: 6594

Comment: Echistatin is a disintegrin derived from the venom of several viper species. The reference from which our biological activity data is from does not specify the exact form of echistatin used in their experiments. The sequence shown here represents the α1 isoform. Echistatin acts as an αVβ3 integrin and glycoprotein IIb/IIIa (αIIbβ3) inhibitor. Echistatin inhibits platelet aggregation [1], i.e. it has an anti-coagulant effect.
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Peptide Sequence Click here for help
Post-translational Modification
Disulphide bond formation between cysteine residues at positions 2 and 11, 7 and 32, 8 and 37, and 20 and 39.