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Synonyms: Ro-09-1978-000 | Ro-091978000 | Xeloda®
capecitabine is an approved drug (FDA (1998), EMA (2001))
Compound class: Synthetic organic
Comment: Capecitabine is a prodrug, that is enzymatically converted to 5-fluorouracil (active agent). It is a thymidylate synthase inhibitor.
1. Carlini LE, Meropol NJ, Bever J, Andria ML, Hill T, Gold P, Rogatko A, Wang H, Blanchard RL. (2005)
UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan.
Clin Cancer Res, 11 (3): 1226-36. [PMID:15709193]
2. Papamichael D. (1999)
The use of thymidylate synthase inhibitors in the treatment of advanced colorectal cancer: current status.
Oncologist, 4 (6): 478-87. [PMID:10631692]