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Synonyms: β-calcitonin gene-related peptide | βCGRP | calcitonin gene-related peptide 2
Compound class: Endogenous peptide in human, mouse or rat
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: β-cgrp
1. Aiyar N, Disa J, Pullen M, Nambi P. (2001)
Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR) in HEK-293 cells.
Mol Cell Biochem, 224 (1-2): 123-33. [PMID:11693189]
2. Fraser NJ, Wise A, Brown J, McLatchie LM, Main MJ, Foord SM. (1999)
The amino terminus of receptor activity modifying proteins is a critical determinant of glycosylation state and ligand binding of calcitonin receptor-like receptor.
Mol Pharmacol, 55: 1054-1059. [PMID:10347248]
3. Hay DL, Christopoulos G, Christopoulos A, Poyner DR, Sexton PM. (2005)
Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes.
Mol Pharmacol, 67 (5): 1655-65. [PMID:15692146]
4. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM. (1998)
RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor.
Nature, 393 (6683): 333-9. [PMID:9620797]