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Synonyms: 6-mercaptoguanine | 6-thioguanine | Lanvis® | Tabloid®
thioguanine is an approved drug (FDA (1966))
Compound class: Synthetic organic
Comment: Inhibits inosine-5'-monophosphate dehydrogenase 1.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Elgemeie GH. (2003)
Thioguanine, mercaptopurine: their analogs and nucleosides as antimetabolites.
Curr Pharm Des, 9 (31): 2627-42. [PMID:14529546]
2. Moreau AC, Paul S, Del Tedesco E, Rinaudo-Gaujous M, Boukhadra N, Genin C, Peyrin-Biroulet L, Roblin X. (2014)
Association between 6-thioguanine nucleotides levels and clinical remission in inflammatory disease: a meta-analysis.
Inflamm Bowel Dis, 20 (3): 464-71. [PMID:24418904]
3. Vethe NT, Bremer S, Bergan S. (2008)
IMP dehydrogenase basal activity in MOLT-4 human leukaemia cells is altered by mycophenolic acid and 6-thioguanosine.
Scand J Clin Lab Invest, 68 (4): 277-85. [PMID:18609073]