Ligand id: 6927

Name: ABT-288

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 40.85
Molecular weight 372.2
XLogP 4.35
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Esbenshade TA, Browman KE, Miller TR, Krueger KM, Komater-Roderwald V, Zhang M, Fox GB, Rueter L, Robb HM, Radek RJ et al.. (2012)
Pharmacological properties and procognitive effects of ABT-288, a potent and selective histamine H3 receptor antagonist.
J. Pharmacol. Exp. Ther., 343 (1): 233-45. [PMID:22815533]
2. National Center for Advancing Translational Sciences (NCATS). 
Accessed on 29/11/2013. Modified on 29/11/2013. Library of Industry-Provided Agents, http://www.ncats.nih.gov/files/ABT-288.pdf
3. Othman AA, Haig G, Florian H, Locke C, Zhang J, Dutta S. (2013)
Safety, tolerability and pharmacokinetics of the histamine H3 receptor antagonist, ABT-288, in healthy young adults and elderly volunteers.
Br J Clin Pharmacol, 75 (5): 1299-311. [PMID:23016924]