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Synonyms: ABT 288 | ABT288
Compound class: Synthetic organic
Comment: ABT-288 is a competitive antagonist with high affinity and selectivity for H3 receptors that enhances the release of acetylcholine and dopamine in rat prefrontal cortex. Has been studied for cognitive impairment associated with Alzheimer’s disease and schizophrenia but is now one of the NCATS repurposing compounds 
1. Esbenshade TA, Browman KE, Miller TR, Krueger KM, Komater-Roderwald V, Zhang M, Fox GB, Rueter L, Robb HM, Radek RJ et al.. (2012)
Pharmacological properties and procognitive effects of ABT-288, a potent and selective histamine H3 receptor antagonist.
J Pharmacol Exp Ther, 343 (1): 233-45. [PMID:22815533]
2. National Center for Advancing Translational Sciences (NCATS).
Accessed on 29/11/2013. Modified on 29/11/2013. Library of Industry-Provided Agents, http://www.ncats.nih.gov/files/ABT-288.pdf
3. Othman AA, Haig G, Florian H, Locke C, Zhang J, Dutta S. (2013)
Safety, tolerability and pharmacokinetics of the histamine H3 receptor antagonist, ABT-288, in healthy young adults and elderly volunteers.
Br J Clin Pharmacol, 75 (5): 1299-311. [PMID:23016924]