Synonyms: BRD 4770 | BRD-4770
Compound class:
Synthetic organic
Comment: BRD4770 may be hydrolysed to BRD9539 (see [2]) in cells, with the latter being the more active compound.
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References |
1. Kubicek S, O'Sullivan RJ, August EM, Hickey ER, Zhang Q, Teodoro ML, Rea S, Mechtler K, Kowalski JA, Homon CA et al.. (2007)
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell, 25 (3): 473-81. [PMID:17289593] |
2. Yuan Y, Wang Q, Paulk J, Kubicek S, Kemp MM, Adams DJ, Shamji AF, Wagner BK, Schreiber SL. (2012)
A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma. ACS Chem Biol, 7 (7): 1152-7. [PMID:22536950] |