Synonyms: Campral®
acamprosate is an approved drug (FDA (2004))
Compound class:
Synthetic organic
Comment: Acamprosate is a NMDA glutamate receptor antagonist and a positive allosteric modulator of GABAA receptors.
Marketed formulations contain acamprosate calcium (PubChem CID 155434). View more information in the IUPHAR Pharmacology Education Project: acamprosate |
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References |
1. De Witte P, Littleton J, Parot P, Koob G. (2005)
Neuroprotective and abstinence-promoting effects of acamprosate: elucidating the mechanism of action. CNS Drugs, 19 (6): 517-37. [PMID:15963001] |
2. Erickson CA, Mullett JE, McDougle CJ. (2010)
Brief report: acamprosate in fragile X syndrome. J Autism Dev Disord, 40 (11): 1412-6. [PMID:20213249] |
3. Erickson CA, Wink LK, Ray B, Early MC, Stiegelmeyer E, Mathieu-Frasier L, Patrick V, Lahiri DK, McDougle CJ. (2013)
Impact of acamprosate on behavior and brain-derived neurotrophic factor: an open-label study in youth with fragile X syndrome. Psychopharmacology (Berl.), 228 (1): 75-84. [PMID:23436129] |