azathioprine

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Ligands
azathioprine

Ligand id: 7120

Name: azathioprine

View more information in the IUPHAR Pharmacology Education Project: azathioprine

Structure and Physico-chemical Properties

2D Structure

Calculated Physico-chemical Properties
Hydrogen bond acceptors	4
Hydrogen bond donors	1
Rotatable bonds	3
Topological polar surface area	143.4
Molecular weight	277.04
XLogP	0.67
No. Lipinski's rules broken	0

Molecular properties generated using the CDK

Summary
Biological activity
Clinical data
References
Structure
Immunopharmacology

References
1. Jones JE, Causey CP, Knuckley B, Slack-Noyes JL, Thompson PR. (2009) Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential. Curr Opin Drug Discov Devel, 12 (5): 616-27. [PMID:19736621]
2. Knuckley B, Luo Y, Thompson PR. (2008) Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors. Bioorg. Med. Chem., 16 (2): 739-45. [PMID:17964793]

References

1. Jones JE, Causey CP, Knuckley B, Slack-Noyes JL, Thompson PR. (2009)
Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential.
Curr Opin Drug Discov Devel, 12 (5): 616-27. [PMID:19736621]

2. Knuckley B, Luo Y, Thompson PR. (2008)
Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors.
Bioorg. Med. Chem., 16 (2): 739-45. [PMID:17964793]