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Synonyms: amfebutamone | BW-323 | Wellbutrin® | Zyban®
bupropion is an approved drug (FDA (1985))
Compound class: Synthetic organic
Comment: The approval status for use of this drug was submitted for re-evaluation by the European Medicines Agency in 2002, following public health concerns around serious adverse reactions associated with its use. These included depression, suicidal thoughts, suicide, seizures, undesirable cardiovascular effects, and angioedema. EU Member States regulatory authorities agreed to keep the product under regular review.
Marketed formulations usually contain bupropion hydrochloride (PubChem CID 62884).
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: bupropion
1. Carroll FI, Blough BE, Abraham P, Mills AC, Holleman JA, Wolckenhauer SA, Decker AM, Landavazo A, McElroy KT, Navarro HA et al.. (2009)
Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction.
J Med Chem, 52 (21): 6768-81. [PMID:19821577]
2. Lapinsky DJ, Aggarwal S, Huang Y, Surratt CK, Lever JR, Foster JD, Vaughan RA. (2009)
A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone.
Bioorg Med Chem, 17 (11): 3770-4. [PMID:19442525]