L-arginine   Click here for help

GtoPdb Ligand ID: 721

Abbreviated name: L-Arg
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 5
Topological polar surface area 127.72
Molecular weight 174.11
XLogP -3.58
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES OC(=O)C(CCCN=C(N)N)N
Isomeric SMILES OC(=O)[C@H](CCCN=C(N)N)N
InChI InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1
InChI Key ODKSFYDXXFIFQN-BYPYZUCNSA-N
References
1. Fiermonte G, Dolce V, David L, Santorelli FM, Dionisi-Vici C, Palmieri F, Walker JE. (2003)
The mitochondrial ornithine transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms.
J. Biol. Chem., 278 (35): 32778-83. [PMID:12807890]
2. Hatanaka T, Huang W, Ling R, Prasad PD, Sugawara M, Leibach FH, Ganapathy V. (2001)
Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A.
Biochim. Biophys. Acta, 1510 (1-2): 10-7. [PMID:11342143]
3. Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H. (2005)
Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids.
Mol. Pharmacol., 67 (3): 589-97. [PMID:15576628]