L-arginine   Click here for help

GtoPdb Ligand ID: 721

Abbreviated name: L-Arg
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 5
Topological polar surface area 127.72
Molecular weight 174.11
XLogP -3.58
No. Lipinski's rules broken 0
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Isomeric SMILES OC(=O)[C@H](CCCN=C(N)N)N
InChI InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1
Natural/Endogenous Targets
GPRC6 receptor
Enzymes Catalysing Reactions with this Compound as a Substrate or Product
Enzyme EC number Reaction Reference
L-Arginine decarboxylase
Endothelial NOS
Inducible NOS
Neuronal NOS
Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
Cationic amino acid transporter 3
Mitochondrial ornithine transporter 2 1
High affinity cationic amino acid transporter 1
Mitochondrial ornithine transporter 1 1
Low affinity cationic amino acid transporter 2
sodium-coupled neutral amino acid transporter 4 2
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
GPRC6 receptor Ligand is endogenous in the given species Hs Agonist Full agonist 4.4 pEC50 - 3
pEC50 4.4 [3]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Ligand mentioned in the following text fields