L-arginine   

GtoPdb Ligand ID: 721

Abbreviated name: L-Arg
2D Structure
Click here for structure editor
Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 5
Topological polar surface area 127.72
Molecular weight 174.11
XLogP -3.58
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES OC(=O)C(CCCN=C(N)N)N
Isomeric SMILES OC(=O)[C@H](CCCN=C(N)N)N
InChI InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1
InChI Key ODKSFYDXXFIFQN-BYPYZUCNSA-N
Natural/Endogenous Targets
Target
GPRC6 receptor
Enzymes Catalysing Reactions with this Compound as a Substrate or Product
Enzyme EC number Reaction Reference
L-Arginine decarboxylase
Endothelial NOS
Inducible NOS
Neuronal NOS
Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
Cationic amino acid transporter 3
Mitochondrial ornithine transporter 2 1
High affinity cationic amino acid transporter 1
Mitochondrial ornithine transporter 1 1
Low affinity cationic amino acid transporter 2
sodium-coupled neutral amino acid transporter 4 2
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
GPRC6 receptor Hs Agonist Full agonist 4.4 pEC50 - 3
pEC50 4.4 [3]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Ligand mentioned in the following text fields