L-arginine   Click here for help

GtoPdb Ligand ID: 721

Abbreviated name: L-Arg
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 5
Topological polar surface area 127.72
Molecular weight 174.11
XLogP -3.58
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES OC(=O)C(CCCN=C(N)N)N
Isomeric SMILES OC(=O)[C@H](CCCN=C(N)N)N
InChI InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1
InChI Key ODKSFYDXXFIFQN-BYPYZUCNSA-N
Natural/Endogenous Targets
Target
GPRC6 receptor
Enzymes Catalysing Reactions with this Compound as a Substrate or Product
Enzyme EC number Reaction Reference
L-Arginine decarboxylase
Endothelial NOS
Inducible NOS
Neuronal NOS
Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
Cationic amino acid transporter 3
Mitochondrial ornithine transporter 2 1
High affinity cationic amino acid transporter 1
Mitochondrial ornithine transporter 1 1
Low affinity cationic amino acid transporter 2
sodium-coupled neutral amino acid transporter 4 2
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
GPRC6 receptor Ligand is endogenous in the given species Hs Agonist Full agonist 4.4 pEC50 - 3
pEC50 4.4 [3]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Ligand mentioned in the following text fields