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Synonyms: Bystolic® | R-65824 | Ro-67555
nebivolol is an approved drug (FDA (2007))
Compound class: Synthetic organic
Comment: Nebivolol is a β-blocker, selective for β1-adrenoceptors.
Marketed formulations may contain nebivolol hydrochloride (PubChem CID ).
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: nebivolol
1. Frazier EP, Michel-Reher MB, van Loenen P, Sand C, Schneider T, Peters SL, Michel MC. (2011)
Lack of evidence that nebivolol is a β₃-adrenoceptor agonist.
Eur J Pharmacol, 654 (1): 86-91. [PMID:21172342]
2. Pauwels PJ, Gommeren W, Van Lommen G, Janssen PA, Leysen JE. (1988)
The receptor binding profile of the new antihypertensive agent nebivolol and its stereoisomers compared with various beta-adrenergic blockers.
Mol Pharmacol, 34 (6): 843-51. [PMID:2462161]