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Synonyms: Adcirca® | Cialis® | IC-351 | IC351
tadalafil is an approved drug (EMA (2002), FDA (2003))
Compound class: Synthetic organic
Comment: Tadafil is a phosphodiesterase type 5 (PDE5) inhibitor.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: tadalafil
1. Forgue ST, Patterson BE, Bedding AW, Payne CD, Phillips DL, Wrishko RE, Mitchell MI. (2006)
Tadalafil pharmacokinetics in healthy subjects.
Br J Clin Pharmacol, 61 (3): 280-8. [PMID:16487221]
2. Mohamed HA, Girgis NM, Wilcken R, Bauer MR, Tinsley HN, Gary BD, Piazza GA, Boeckler FM, Abadi AH. (2011)
Synthesis and molecular modeling of novel tetrahydro-β-carboline derivatives with phosphodiesterase 5 inhibitory and anticancer properties.
J Med Chem, 54 (2): 495-509. [PMID:21189023]