flutemetamol   Click here for help

GtoPdb Ligand ID: 7342

Synonyms: 18F-flutemetamol | [18F]flutemetamol | flutemetamol F18
Approved drug  Ligand is labelled  Ligand is radioactive
flutemetamol is an approved drug (FDA (2013), EMA (2014))
Compound class: Synthetic organic
Comment: Flutemetamol F-18 (Vizamyl GE Healthcare) is a positron emission tomography (PET) radiotracer approved in 2013 that binds to amyloid plaques in Alzheimer's disease neurodegeneration. However imaging agents have been granted only narrow approval since they can not be used to definitively diagnose Alzheimer's disease or to gauge treatment effectiveness, only to support other diagnostic criteria [2].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 73.39
Molecular weight 274.06
XLogP 2.9
No. Lipinski's rules broken 0
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Canonical SMILES CNc1ccc(cc1F)c1nc2c(s1)cc(cc2)O
Isomeric SMILES CNc1ccc(cc1[18F])c1nc2c(s1)cc(cc2)O
InChI InChI=1S/C14H11FN2OS/c1-16-11-4-2-8(6-10(11)15)14-17-12-5-3-9(18)7-13(12)19-14/h2-7,16,18H,1H3/i15-1
1. Herholz K, Ebmeier K. (2011)
Clinical amyloid imaging in Alzheimer's disease.
Lancet Neurol, 10 (7): 667-70. [PMID:21683932]
2. Williams SC. (2013)
Alzheimer's imaging agents struggle to find a market outside trials.
Nat Med, 19 (12): 1551. [PMID:24309640]
3. Zha Z, Choi SR, Ploessl K, Lieberman BP, Qu W, Hefti F, Mintun M, Skovronsky D, Kung HF. (2011)
Multidentate (18)F-polypegylated styrylpyridines as imaging agents for Aβ plaques in cerebral amyloid angiopathy (CAA).
J Med Chem, 54 (23): 8085-98. [PMID:22011144]