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Synonyms: ABT 384 | ABT384
Compound class: Synthetic organic
Comment: A range of medical conditions, including major depressive disorder and Alzheimer's disease, have been associated with excess levels of the stress hormone cortisol. ABT-384 is a potent and selective inhibitor of 11-beta-hydroxysteroid dehydrogenase type 1 (HSD-1) that generates cortisol. It has completed a phase 1 trial  but failed a phase II trial for Alzheimer's disease . ChEMBL represents this compound with specified stereochemistry with the entry CHEMBL222670.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. An G, Liu W, Katz DA, Marek G, Awni W, Dutta S. (2013)
Effect of ketoconazole on the pharmacokinetics of the 11β-hydroxysteroid dehydrogenase type 1 inhibitor ABT-384 and its two active metabolites in healthy volunteers: population analysis of data from a drug-drug interaction study.
Drug Metab Dispos, 41 (5): 1035-45. [PMID:23431112]
2. Katz DA, Liu W, Locke C, Jacobson P, Barnes DM, Basu R, An G, Rieser MJ, Daszkowski D, Groves F et al.. (2013)
Peripheral and central nervous system inhibition of 11β-hydroxysteroid dehydrogenase type 1 in man by the novel inhibitor ABT-384.
Transl Psychiatry, 3: e295. [PMID:23982627]
3. Marek GJ, Katz DA, Meier A, Greco 4th N, Zhang W, Liu W, Lenz RA. (2014)
Efficacy and safety evaluation of HSD-1 inhibitor ABT-384 in Alzheimer's disease.
Alzheimers Dement, 10 (5 Suppl): S364-73. [PMID:24418055]
4. Sorensen B, Rohde J, Wang J, Fung S, Monzon K, Chiou W, Pan L, Deng X, Stolarik D, Frevert EU et al.. (2006)
Adamantane 11-beta-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction.
Bioorg Med Chem Lett, 16 (23): 5958-62. [PMID:16996734]