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Synonyms: AV-411 | KC-404 | Ketas® | MN-166
ibudilast is an approved drug
Compound class: Synthetic organic
Comment: Ibudilast is a phosphodiesterase (PDE) inhibitor antiinflammatory drug. See the Biological activity tab for affinity data across a range of PDE isozymes.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Allcock RW, Blakli H, Jiang Z, Johnston KA, Morgan KM, Rosair GM, Iwase K, Kohno Y, Adams DR. (2011)
Phosphodiesterase inhibitors. Part 1: Synthesis and structure-activity relationships of pyrazolopyridine-pyridazinone PDE inhibitors developed from ibudilast.
Bioorg Med Chem Lett, 21 (11): 3307-12. [PMID:21530250]
2. Cho Y, Crichlow GV, Vermeire JJ, Leng L, Du X, Hodsdon ME, Bucala R, Cappello M, Gross M, Gaeta F et al.. (2010)
Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast.
Proc Natl Acad Sci USA, 107 (25): 11313-8. [PMID:20534506]
3. Fox RJ, Coffey CS, Conwit R, Cudkowicz ME, Gleason T, Goodman A, Klawiter EC, Matsuda K, McGovern M, Naismith RT et al.. (2018)
Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis.
N Engl J Med, 379 (9): 846-855. [PMID:30157388]
4. Kodimuthali A, Jabaris SS, Pal M. (2008)
Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease.
J Med Chem, 51 (18): 5471-89. [PMID:18686943]