lenvatinib

Ligand id: 7426

Name: lenvatinib

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 115.57
Molecular weight 426.11
XLogP 2.47
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Piscaglia F, Baron A, Park JW, Han G, Jassem J et al.. (2018)
Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial.
Lancet, 391 (10126): 1163-1173. [PMID:29433850]
2. Musumeci F, Radi M, Brullo C, Schenone S. (2012)
Vascular endothelial growth factor (VEGF) receptors: drugs and new inhibitors.
J. Med. Chem., 55 (24): 10797-822. [PMID:23098265]