fospropofol   

GtoPdb Ligand ID: 7475

Synonyms: Lusedra®
fospropofol is an approved drug (FDA (2008))
Compound class: Synthetic organic
Comment: Fospropofol is a prodrug which undergoes hepatic conversion to the active moeity, propofol.
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 85.8
Molecular weight 288.11
XLogP 2.52
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES CC(c1cccc(c1OCOP(=O)(O)O)C(C)C)C
Isomeric SMILES CC(c1cccc(c1OCOP(=O)(O)O)C(C)C)C
InChI InChI=1S/C13H21O5P/c1-9(2)11-6-5-7-12(10(3)4)13(11)17-8-18-19(14,15)16/h5-7,9-10H,8H2,1-4H3,(H2,14,15,16)
InChI Key QVNNONOFASOXQV-UHFFFAOYSA-N
References
1. Bennett DJ, Anderson A, Buchanan K, Byford A, Cooke A, Gemmell DK, Hamilton NM, Maidment MS, McPhail P, Stevenson DF et al.. (2003)
Novel water soluble 2,6-dimethoxyphenyl ester derivatives with intravenous anaesthetic activity.
Bioorg. Med. Chem. Lett., 13 (12): 1971-5. [PMID:12781176]
2. Cooke A, Anderson A, Buchanan K, Byford A, Gemmell D, Hamilton N, McPhail P, Miller S, Sundaram H, Vijn P. (2001)
Water-soluble propofol analogues with intravenous anaesthetic activity.
Bioorg. Med. Chem. Lett., 11 (7): 927-30. [PMID:11294393]
3. Haeseler G, Karst M, Foadi N, Gudehus S, Roeder A, Hecker H, Dengler R, Leuwer M. (2008)
High-affinity blockade of voltage-operated skeletal muscle and neuronal sodium channels by halogenated propofol analogues.
Br. J. Pharmacol., 155 (2): 265-75. [PMID:18574460]
4. Haeseler G, Leuwer M. (2003)
High-affinity block of voltage-operated rat IIA neuronal sodium channels by 2,6 di-tert-butylphenol, a propofol analogue.
Eur J Anaesthesiol, 20 (3): 220-4. [PMID:12650493]
5. Krasowski MD, Hong X, Hopfinger AJ, Harrison NL. (2002)
4D-QSAR analysis of a set of propofol analogues: mapping binding sites for an anesthetic phenol on the GABA(A) receptor.
J. Med. Chem., 45 (15): 3210-21. [PMID:12109905]
6. Trapani G, Latrofa A, Franco M, Altomare C, Sanna E, Usala M, Biggio G, Liso G. (1998)
Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological profile at recombinant human GABAA receptors.
J. Med. Chem., 41 (11): 1846-54. [PMID:9599235]
7. Yip GM, Chen ZW, Edge CJ, Smith EH, Dickinson R, Hohenester E, Townsend RR, Fuchs K, Sieghart W, Evers AS et al.. (2013)
A propofol binding site on mammalian GABAA receptors identified by photolabeling.
Nat. Chem. Biol., 9 (11): 715-20. [PMID:24056400]