AZD7325   Click here for help

GtoPdb Ligand ID: 7712

Synonyms: AZD 7325 | AZD-7325
Compound class: Synthetic organic
Comment: AZD7325 was developed as a positive allosteric modulator of the GABAA α2 and α3 channels and was investigated as a treatment for generalised anxiety disorder. This compound is now included in AstaZeneca's Open Innovation Pharmacology Toolbox.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 90.13
Molecular weight 354.15
XLogP 3.2
No. Lipinski's rules broken 0
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Canonical SMILES CCCNC(=O)c1nnc2c(c1N)cccc2c1c(F)cccc1OC
Isomeric SMILES CCCNC(=O)c1nnc2c(c1N)cccc2c1c(F)cccc1OC
InChI InChI=1S/C19H19FN4O2/c1-3-10-22-19(25)18-16(21)12-7-4-6-11(17(12)23-24-18)15-13(20)8-5-9-14(15)26-2/h4-9H,3,10H2,1-2H3,(H2,21,23)(H,22,25)
1. Alhambra C, Becker C, Blake T, Chang AH, Damewood Jr JR, Daniels T, Dembofsky BT, Gurley DA, Hall JE, Herzog KJ et al.. (2011)
Development and SAR of functionally selective allosteric modulators of GABAA receptors.
Bioorg Med Chem, 19 (9): 2927-38. [PMID:21498079]
2. AstraZeneca. 
Accessed on 11/09/2014. Modified on 11/09/2014.,