Z944   Click here for help

GtoPdb Ligand ID: 7718

Synonyms: PRAX-944 | PRAX944 | Z 944 | Z-944
PDB Ligand
Compound class: Synthetic organic
Comment: PRAX-944 (Z-944) is a T-type calcium channel blocker/inhibitor [2].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 61.44
Molecular weight 383.18
XLogP 3.27
No. Lipinski's rules broken 0
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Canonical SMILES O=C(NC(C)(C)C)CN1CCC(CC1)CNC(=O)c1cc(F)cc(c1)Cl
Isomeric SMILES O=C(NC(C)(C)C)CN1CCC(CC1)CNC(=O)c1cc(F)cc(c1)Cl
InChI InChI=1S/C19H27ClFN3O2/c1-19(2,3)23-17(25)12-24-6-4-13(5-7-24)11-22-18(26)14-8-15(20)10-16(21)9-14/h8-10,13H,4-7,11-12H2,1-3H3,(H,22,26)(H,23,25)
1. Matthews LG, Puryear CB, Correia SS, Srinivasan S, Belfort GM, Pan MK, Kuo SH. (2023)
T-type calcium channels as therapeutic targets in essential tremor and Parkinson's disease.
Ann Clin Transl Neurol, 10 (4): 462-483. [PMID:36738196]
2. Scott L, Puryear CB, Belfort GM, Raines S, Hughes ZA, Matthews LG, Ravina B, Wittmann M. (2022)
Translational Pharmacology of PRAX-944, a Novel T-Type Calcium Channel Blocker in Development for the Treatment of Essential Tremor.
Mov Disord, 37 (6): 1193-1201. [PMID:35257414]
3. Tringham E, Powell KL, Cain SM, Kuplast K, Mezeyova J, Weerapura M, Eduljee C, Jiang X, Smith P, Morrison JL et al.. (2012)
T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures.
Sci Transl Med, 4 (121): 121ra19. [PMID:22344687]