CCL8   Click here for help

GtoPdb Ligand ID: 772

Synonyms: monocyte chemotactic protein-2
Immunopharmacology Ligand
Comment: CCL8 (also known as MCP-2) is a CC family chemokine.
Species: Human
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1. Blaszczyk J, Coillie EV, Proost P, Damme JV, Opdenakker G, Bujacz GD, Wang JM, Ji X. (2000)
Complete crystal structure of monocyte chemotactic protein-2, a CC chemokine that interacts with multiple receptors.
Biochemistry, 39 (46): 14075-81. [PMID:11087354]
2. Lüttichau HR, Clark-Lewis I, Jensen PØ, Moser C, Gerstoft J, Schwartz TW. (2003)
A highly selective CCR2 chemokine agonist encoded by human herpesvirus 6.
J Biol Chem, 278 (13): 10928-33. [PMID:12554737]
3. Proost P, Struyf S, Couvreur M, Lenaerts JP, Conings R, Menten P, Verhaert P, Wuyts A, Van Damme J. (1998)
Posttranslational modifications affect the activity of the human monocyte chemotactic proteins MCP-1 and MCP-2: identification of MCP-2(6-76) as a natural chemokine inhibitor.
J Immunol, 160 (8): 4034-41. [PMID:9558113]
4. Ruffing N, Sullivan N, Sharmeen L, Sodroski J, Wu L. (1998)
CCR5 has an expanded ligand-binding repertoire and is the primary receptor used by MCP-2 on activated T cells.
Cell Immunol, 189 (2): 160-8. [PMID:9790730]