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Synonyms: PF-04950615 | RN-316 | RN316
Compound class: Antibody
Comment: Bococizumab is an experimental monoclonal antibody directed against PCSK9 . Anti-PCSK9 antibodies are under intense clinical lead scrutiny, as the successors to statins for the treatment of hyperlipidemia and associated atherosclerotic cardiovascular disease. Peptide sequences for this antibody are available from its IMGT link. Based on sequence alignment bococizumab relates to antibody clone L1L3 in patent US8080243, with SEQ IDs 53 and 54 matching the sequences in the INN record for bococizumab.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Liang H et al.
Isolated antibody which specifically binds to PCSK9.
Patent number: US8080243. Assignee: Rinat Neuroscience Corp., Pfizer Inc.. Priority date: 12/09/2008. Publication date: 20/12/2011.