AZD2423   Click here for help

GtoPdb Ligand ID: 7825

Synonyms: AZD 2423 | AZD-2423
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: AZD2423 is a non-competitive negative allosteric modulator of the chemokine receptor CCR2. See the slideset presented by John G Cumming at the 17th RSC/SCI Medicinal Chemistry Symposium, 9th September, 2013, Churchill College, Cambridge [1] for further details of the discovery and molecular mechanism of this compound.
This compound was in the AstraZeneca/NCATS repurposing list from 2012.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 67.92
Molecular weight 411.18
XLogP 1.19
No. Lipinski's rules broken 0
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Canonical SMILES O=C(N1CCN(CC1)C(=O)C1NCCN(C1)C(C)C)Nc1ccc(c(c1)F)Cl
Isomeric SMILES O=C(N1CCN(CC1)C(=O)[C@@H]1NCCN(C1)C(C)C)Nc1ccc(c(c1)F)Cl
InChI InChI=1S/C19H27ClFN5O2/c1-13(2)26-6-5-22-17(12-26)18(27)24-7-9-25(10-8-24)19(28)23-14-3-4-15(20)16(21)11-14/h3-4,11,13,17,22H,5-10,12H2,1-2H3,(H,23,28)/t17-/m1/s1
1. Cumming JG. 
Slideset: CCR2 antagonists for the treatment of neuropathic pain. The discovery and development of AZD2423.
Accessed on 28/10/2014. Modified on 28/10/2014.
2. Kalliomäki J, Attal N, Jonzon B, Bach FW, Huizar K, Ratcliffe S, Eriksson B, Janecki M, Danilov A, Bouhassira D et al.. (2013)
A randomized, double-blind, placebo-controlled trial of a chemokine receptor 2 (CCR2) antagonist in posttraumatic neuralgia.
Pain, 154 (5): 761-7. [PMID:23523116]