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Synonyms: LBQ-657 | LBQ657
Compound class: Synthetic organic
Comment: This compound is a neprilysin (MME-membrane metallo-endopeptidase) inhibitor generated from the prodrug sacubitril. Sacubitril is a component of the approved fixed-dose combination drug Entresto® (sacubitril plus valsartan). The chemical database relationships are detailed in this blogpost.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Swedberg K.
Inhibition of the renin - angiotensin system – present and future challenges.
Accessed on 02/11/2014. Modified on 02/11/2014. Heart Failure Update 2014, http://www.hfupdate.ca/pdfs/Inhibition%20of%20th%20eRenin-Angiotensin%20System_Present%20and%20Future%20Challenges_Dr.%20Swedberg.pdf