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Compound class: Synthetic organic
Comment: Bisphenol A acts as an estrogen mimic [3-4] and may also have anti-androgenic activity .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Lee HJ, Chattopadhyay S, Gong EY, Ahn RS, Lee K. (2003)
Antiandrogenic effects of bisphenol A and nonylphenol on the function of androgen receptor.
Toxicol Sci, 75 (1): 40-6. [PMID:12805653]
2. Maruyama K, Nakamura M, Tomoshige S, Sugita K, Makishima M, Hashimoto Y, Ishikawa M. (2013)
Structure-activity relationships of bisphenol A analogs at estrogen receptors (ERs): discovery of an ERα-selective antagonist.
Bioorg Med Chem Lett, 23 (14): 4031-6. [PMID:23768907]
3. Yiu KW, Lee CK, Kwok KC, Cheung NH. (2014)
Measuring the kinetics of the binding of xenoestrogens and estrogen receptor alpha by fluorescence polarization.
Environ Sci Technol, 48 (19): 11591-9. [PMID:25180905]
4. Zhuang S, Zhang C, Liu W. (2014)
Atomic Insights into Distinct Hormonal Activities of Bisphenol A Analogues toward PPARγ and ERα Receptors.
Chem Res Toxicol, 27 (10): 1769-79. [PMID:25233466]