sargramostim   Click here for help

GtoPdb Ligand ID: 7905

Synonyms: Leukine®
Approved drug
sargramostim is an approved drug (FDA (1991))
Comment: Sargramostim is recombinant human GM-CSF, produced in E.coli. Compared to the endogenous peptide sargramostim has a Arg>Leu substitution at residue 23.
1. Hodi FS, Lee S, McDermott DF, Rao UN, Butterfield LH, Tarhini AA, Leming P, Puzanov I, Shin D, Kirkwood JM. (2014)
Ipilimumab plus sargramostim vs ipilimumab alone for treatment of metastatic melanoma: a randomized clinical trial.
JAMA, 312 (17): 1744-53. [PMID:25369488]