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Synonyms: imidazopyridine derivative 8c [PMID 17601739]  | PIK 75 | PIK75
Compound class: Synthetic organic
Comment: The discovery of PIK-75 is described by Hayakawa et al. (2007) , where it is compound 8c.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Hayakawa M, Kawaguchi K, Kaizawa H, Koizumi T, Ohishi T, Yamano M, Okada M, Ohta M, Tsukamoto S, Raynaud FI et al.. (2007)
Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors.
Bioorg Med Chem, 15 (17): 5837-44. [PMID:17601739]
2. Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O, Loewith R, Stokoe D, Balla A, Toth B et al.. (2006)
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.
Cell, 125 (4): 733-47. [PMID:16647110]
3. Zheng Z, Amran SI, Thompson PE, Jennings IG. (2011)
Isoform-selective inhibition of phosphoinositide 3-kinase: identification of a new region of nonconserved amino acids critical for p110α inhibition.
Mol Pharmacol, 80 (4): 657-64. [PMID:21778304]