Ligand id: 8027

Name: AZD3409

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 17
Topological polar surface area 142.95
Molecular weight 574.24
XLogP 6.07
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

1. Appels NM, Bolijn MJ, van Eijndhoven MA, Stephens TC, Beijnen JH, Schellens JH. (2011)
Characterization of the in vitro activity of AZD3409, a novel prenyl transferase inhibitor.
Cancer Chemother. Pharmacol., 67 (1): 137-45. [PMID:20229082]
2. Downward J. (2003)
Targeting RAS signalling pathways in cancer therapy.
Nat. Rev. Cancer, 3 (1): 11-22. [PMID:12509763]
3. Streeper R, Campos D, Carrizales G, Stephens TC, Izbicka E. (2006)
Regulation of tumor signaling pathways by AZD3409 in vitro.
Anticancer Res., 26 (6B): 4185-9. [PMID:17201131]