AZD3409   Click here for help

GtoPdb Ligand ID: 8027

Synonyms: AZD 3409 | AZD-3409
Compound class: Synthetic organic
Comment: AZD3409 is an an orally active double prodrug, peptidomimetic type farnesyltransferase inhibitor (FTI). It is a double prodrug in that it has its thiol and carboxylate groups blocked to reduce toxicity.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 17
Topological polar surface area 142.95
Molecular weight 574.24
XLogP 6.07
No. Lipinski's rules broken 2
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES FCCc1ccc(cc1C(=C)NC(C(=O)OC(C)C)CCSC)NCC1CCC(N1)SC(=O)c1cccnc1
Isomeric SMILES FCCc1ccc(cc1C(=C)N[C@H](C(=O)OC(C)C)CCSC)NC[C@@H]1CC[C@@H](N1)SC(=O)c1cccnc1
InChI InChI=1S/C29H39FN4O3S2/c1-19(2)37-28(35)26(12-15-38-4)33-20(3)25-16-23(8-7-21(25)11-13-30)32-18-24-9-10-27(34-24)39-29(36)22-6-5-14-31-17-22/h5-8,14,16-17,19,24,26-27,32-34H,3,9-13,15,18H2,1-2,4H3/t24-,26-,27-/m0/s1
InChI Key GIJNHMGFNKZBIR-URORMMCBSA-N
References
1. Appels NM, Bolijn MJ, van Eijndhoven MA, Stephens TC, Beijnen JH, Schellens JH. (2011)
Characterization of the in vitro activity of AZD3409, a novel prenyl transferase inhibitor.
Cancer Chemother Pharmacol, 67 (1): 137-45. [PMID:20229082]
2. Downward J. (2003)
Targeting RAS signalling pathways in cancer therapy.
Nat Rev Cancer, 3 (1): 11-22. [PMID:12509763]
3. Streeper R, Campos D, Carrizales G, Stephens TC, Izbicka E. (2006)
Regulation of tumor signaling pathways by AZD3409 in vitro.
Anticancer Res, 26 (6B): 4185-9. [PMID:17201131]