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Synonyms: Compound 310 [US8778951]  | Example 93 [US8778951]
Compound class: Synthetic organic
Comment: NVP-2 is one of the compounds claimed in patent WO2011012661 . NVP-2 is an inhibitor of the cyclin-dependent kinase CDK9. It was a preclinical lead compound.
PubChem CID 77201406 represents the compound without stereochemistry, and PubChem CID 66937006 has stereochemistry specified at only one of the chiral centers.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Barsanti PA et al.. (2011)
Pyridine and pyrazine derivatives as protein kinase modulators.
Patent number: WO2011012661. Assignee: Novartis Ag. Priority date: 30/07/2009. Publication date: 03/02/2011.
2. Barsanti PA, Hu C, Jin J, Keyes R, Kucejko R, Lin X, Pan Y, Pfister KB, Sendzik M, Sutton J et al.. (2014)
Heteroaryl compounds and their uses.
Patent number: US8778951. Assignee: Novartis Ag. Priority date: 30/07/2009. Publication date: 15/07/2014.