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Compound class: Synthetic organic
Comment: MRT67307 is a non-selective inhibitor of TANK-binding kinase 1 (TBK1)  with utility for the study of the roles played by IKKs and IKK-related kinases in the regulation of the type I interferon response in innate immunity.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Clark K, Peggie M, Plater L, Sorcek RJ, Young ER, Madwed JB, Hough J, McIver EG, Cohen P. (2011)
Novel cross-talk within the IKK family controls innate immunity.
Biochem. J., 434 (1): 93-104. [PMID:21138416]
2. Yu J, Zhou X, Chang M, Nakaya M, Chang JH, Xiao Y, Lindsey JW, Dorta-Estremera S, Cao W, Zal A et al.. (2015)
Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation.
Nat Commun, 6: 6074. [PMID:25606824]