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Synonyms: PD-166285 | PD0166285 
Compound class: Synthetic organic
Comment: PD166285 was originally reported as a tyrosine kinase inhibitor [1-2,4], and has subsequently been identified as an inhibitor of Wee1  and Myt1 (PKMYT1) , two cyclin-dependent kinase (CDK) inhibitory kinases involved in regulating the cell cycle.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Klutchko SR, Hamby JM, Boschelli DH, Wu Z, Kraker AJ, Amar AM, Hartl BG, Shen C, Klohs WD, Steinkampf RW et al.. (1998)
2-Substituted aminopyrido[2,3-d]pyrimidin-7(8H)-ones. structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity.
J Med Chem, 41 (17): 3276-92. [PMID:9703473]
2. Panek RL, Lu GH, Klutchko SR, Batley BL, Dahring TK, Hamby JM, Hallak H, Doherty AM, Keiser JA. (1997)
In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor.
J Pharmacol Exp Ther, 283 (3): 1433-44. [PMID:9400019]
3. Rohe A, Erdmann F, Bäßler C, Wichapong K, Sippl W, Schmidt M. (2012)
In vitro and in silico studies on substrate recognition and acceptance of human PKMYT1, a Cdk1 inhibitory kinase.
Bioorg Med Chem Lett, 22 (2): 1219-23. [PMID:22189141]
4. Trumpp-Kallmeyer S, Rubin JR, Humblet C, Hamby JM, Showalter HD. (1998)
Development of a binding model to protein tyrosine kinases for substituted pyrido[2,3-d]pyrimidine inhibitors.
J Med Chem, 41 (11): 1752-63. [PMID:9599227]
5. Wang Y, Li J, Booher RN, Kraker A, Lawrence T, Leopold WR, Sun Y. (2001)
Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator.
Cancer Res, 61 (22): 8211-7. [PMID:11719452]