Synonyms: 5(S)-(2'-hydroxyethoxy)-20(S)-camptothecin | 5(S)-(2'-hydroxyethoxy)-20(S)-CPT
Compound class:
Synthetic organic
Comment: S-isomer of DRF-1042 is a derivative of camptothecin, a natural quinoline alkaloid with cytotoxic effects, which acts to inhibit DNA topoisomerase I. This compound only contains the (S) stereoisomer, as described in patent US20110177161 [1]. PubChem CID 23631031 represents the molecule with no specified stereochemistry at the 5 position.
Two camptothecin derivatives are already approved for clinical use: topotecan and irinotecan. |
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References |
1. Nekkanti VK, Karatgi PJ, Paithankar M, Pillai RS, Venkateswarlu A, Shanvas A, Kumar RA, Ramesh M, Raju S, Subrahmanyam D et al.. (2011)
Pharmaceutical compositions of [5(s)-(2'-hydroxyethoxy)-20(s)-camptothecin. Patent number: US20110177161. Assignee: Dr. Reddy's Laboratories Limited,. Priority date: 24/05/2007. Publication date: 21/07/2011. |