GtoPdb Ligand ID: 8300

Synonyms: DSC-127 | DSC127 | NorLeu3-A(1-7) [1]
Comment: Aclerastide is a synthetic analogue of angiotensin (1-7).
1. Balingit PP, Armstrong DG, Reyzelman AM, Bolton L, Verco SJ, Rodgers KE, Nigh KA, diZerega GS. (2012)
NorLeu3-A(1-7) stimulation of diabetic foot ulcer healing: results of a randomized, parallel-group, double-blind, placebo-controlled phase 2 clinical trial.
Wound Repair Regen, 20 (4): 482-90. [PMID:22672145]
2. Nguyen TT, Ding D, Wolter WR, Champion MM, Hesek D, Lee M, PĂ©rez RL, Schroeder VA, Suckow MA, Mobashery S et al.. (2018)
Expression of active matrix metalloproteinase-9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers.
Eur. J. Pharmacol., 834: 77-83. [PMID:30012502]
3. Rodgers KE, Roda N, Felix JE, Espinoza T, Maldonado S, diZerega G. (2003)
Histological evaluation of the effects of angiotensin peptides on wound repair in diabetic mice.
Exp. Dermatol., 12 (6): 784-90. [PMID:14714558]