aclerastide

Home
Ligands
aclerastide

GtoPdb Ligand ID: 8300

Synonyms: DSC-127 | DSC127 | NorLeu³-A(1-7) [1]

Compound class: Peptide or derivative

Comment: Aclerastide is a synthetic analogue of angiotensin (1-7).

References
1. Balingit PP, Armstrong DG, Reyzelman AM, Bolton L, Verco SJ, Rodgers KE, Nigh KA, diZerega GS. (2012) NorLeu3-A(1-7) stimulation of diabetic foot ulcer healing: results of a randomized, parallel-group, double-blind, placebo-controlled phase 2 clinical trial. Wound Repair Regen, 20 (4): 482-90. [PMID:22672145]
2. Nguyen TT, Ding D, Wolter WR, Champion MM, Hesek D, Lee M, Pérez RL, Schroeder VA, Suckow MA, Mobashery S et al.. (2018) Expression of active matrix metalloproteinase-9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers. Eur J Pharmacol, 834: 77-83. [PMID:30012502]
3. Rodgers KE, Roda N, Felix JE, Espinoza T, Maldonado S, diZerega G. (2003) Histological evaluation of the effects of angiotensin peptides on wound repair in diabetic mice. Exp Dermatol, 12 (6): 784-90. [PMID:14714558]

References

1. Balingit PP, Armstrong DG, Reyzelman AM, Bolton L, Verco SJ, Rodgers KE, Nigh KA, diZerega GS. (2012)
NorLeu3-A(1-7) stimulation of diabetic foot ulcer healing: results of a randomized, parallel-group, double-blind, placebo-controlled phase 2 clinical trial.
Wound Repair Regen, 20 (4): 482-90. [PMID:22672145]

2. Nguyen TT, Ding D, Wolter WR, Champion MM, Hesek D, Lee M, Pérez RL, Schroeder VA, Suckow MA, Mobashery S et al.. (2018)
Expression of active matrix metalloproteinase-9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers.
Eur J Pharmacol, 834: 77-83. [PMID:30012502]

3. Rodgers KE, Roda N, Felix JE, Espinoza T, Maldonado S, diZerega G. (2003)
Histological evaluation of the effects of angiotensin peptides on wound repair in diabetic mice.
Exp Dermatol, 12 (6): 784-90. [PMID:14714558]