minimised relaxin-3 analogue 2   Click here for help

GtoPdb Ligand ID: 8336

Comment: A synthetic analogue of human relaxin-3 comprising a synthetic truncated from of the A chain, and a B chain matching the natural sequence of relaxin-3 B chain. The sequence of the A chain can be found from the link on the structure tab of this ligand page, and please see the ligand entry for relaxin-3 (B chain) for the sequence of the B chain. N.B. The truncated A chain subunit of this peptide is also a subunit of minimised relaxin-3 analogue 3.
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References
1. Shabanpoor F, Akhter Hossain M, Ryan PJ, Belgi A, Layfield S, Kocan M, Zhang S, Samuel CS, Gundlach AL, Bathgate RA et al.. (2012)
Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family peptide 3 receptor (RXFP3) over RXFP1.
J Med Chem, 55 (4): 1671-81. [PMID:22257012]