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Synonyms: compound 17k [PMID 20420387] | GSK-1070916
Compound class: Synthetic organic
Comment: GSK1070916 is reported to be an ATP-competitive, potent and selective inhibitor of Aurora kinases B and C .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Adams ND, Adams JL, Burgess JL, Chaudhari AM, Copeland RA, Donatelli CA, Drewry DH, Fisher KE, Hamajima T, Hardwicke MA et al.. (2010)
Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase.
J Med Chem, 53 (10): 3973-4001. [PMID:20420387]
2. Andrews PD, Knatko E, Moore WJ, Swedlow JR. (2003)
Mitotic mechanics: the auroras come into view.
Curr Opin Cell Biol, 15 (6): 672-83. [PMID:14644191]
3. Girdler F, Gascoigne KE, Eyers PA, Hartmuth S, Crafter C, Foote KM, Keen NJ, Taylor SS. (2006)
Validating Aurora B as an anti-cancer drug target.
J Cell Sci, 119 (Pt 17): 3664-75. [PMID:16912073]
4. Keen N, Taylor S. (2004)
Aurora-kinase inhibitors as anticancer agents.
Nat Rev Cancer, 4 (12): 927-36. [PMID:15573114]