(-)-englerin A   Click here for help

GtoPdb Ligand ID: 8372

Compound class: Synthetic organic
Comment: (-)-englerin A is a plant extract from the bark of Phyllanthus engleri [4]. (-)-englerin A is a potent and selective agonist of TRPC4 and TRPC5 calcium channels [1] with cytotoxic activity selective for several renal cancer cell lines [4]. The (+) enantiomer is inactive against the same cells [3]. The compound has been chemically synthesised [2-3,5].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 82.06
Molecular weight 442.24
XLogP 4.66
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES OCC(=O)OC1CC2(OC1(C)C1CCC(C1C2OC(=O)C=Cc1ccccc1)C)C(C)C
Isomeric SMILES OCC(=O)O[C@@H]1C[C@@]2(O[C@@]1(C)[C@@H]1CC[C@H]([C@H]1[C@@H]2OC(=O)/C=C/c1ccccc1)C)C(C)C
InChI InChI=1S/C26H34O6/c1-16(2)26-14-20(30-22(29)15-27)25(4,32-26)19-12-10-17(3)23(19)24(26)31-21(28)13-11-18-8-6-5-7-9-18/h5-9,11,13,16-17,19-20,23-24,27H,10,12,14-15H2,1-4H3/b13-11+/t17-,19-,20-,23-,24+,25+,26-/m1/s1
InChI Key GACOFEKSDCOVMV-RRYXBOBMSA-N
References
1. Akbulut Y, Gaunt HJ, Muraki K, Ludlow MJ, Amer MS, Bruns A, Vasudev NS, Radtke L, Willot M, Hahn S et al.. (2015)
(-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels.
Angew Chem Int Ed Engl, 54 (12): 3787-91. [PMID:25707820]
2. Molawi K, Delpont N, Echavarren AM. (2010)
Enantioselective synthesis of (-)-englerins A and B.
Angew Chem Int Ed Engl, 49 (20): 3517-9. [PMID:20544903]
3. Radtke L, Willot M, Sun H, Ziegler S, Sauerland S, Strohmann C, Fröhlich R, Habenberger P, Waldmann H, Christmann M. (2011)
Total synthesis and biological evaluation of (-)-englerin A and B: synthesis of analogues with improved activity profile.
Angew Chem Int Ed Engl, 50 (17): 3998-4002. [PMID:21472928]
4. Ratnayake R, Covell D, Ransom TT, Gustafson KR, Beutler JA. (2009)
Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri.
Org Lett, 11 (1): 57-60. [PMID:19061394]
5. Zhou Q, Chen X, Ma D. (2010)
Asymmetric, protecting-group-free total synthesis of (-)-englerin A.
Angew Chem Int Ed Engl, 49 (20): 3513-6. [PMID:20544902]