Ligand id: 8433

Name: AS-19

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 21.06
Molecular weight 283.2
XLogP 3.02
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Brenchat A, Romero L, García M, Pujol M, Burgueño J, Torrens A, Hamon M, Baeyens JM, Buschmann H, Zamanillo D et al.. (2009)
5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice.
Pain, 141 (3): 239-47. [PMID:19118950]
2. Kim Y, Kim J, Tae J, Roth BL, Rhim H, Keum G, Nam G, Choo H. (2013)
Discovery of aryl-biphenyl-2-ylmethylpiperazines as novel scaffolds for 5-HT(7) ligands and role of the aromatic substituents in binding to the target receptor.
Bioorg. Med. Chem., 21 (9): 2568-76. [PMID:23541835]
3. Meneses A, Perez-Garcia G, Liy-Salmeron G, Flores-Galvez D, Castillo C, Castillo E. (2008)
The effects of the 5-HT(6) receptor agonist EMD and the 5-HT(7) receptor agonist AS19 on memory formation.
Behav. Brain Res., 195 (1): 112-9. [PMID:18191236]