tarextumab   Click here for help

GtoPdb Ligand ID: 8453

Synonyms: OMP-59R5
Compound class: Antibody
Comment: Tarextumab is fully human IgG2 monoclonal antibody targeting Notch receptors 2 and 3.
Peptide sequence information for this antibody is available from its IMGT/mAb-DB record. A BLAST search using the peptide sequence of the variable region of the heavy chain of tarextumab reveals 100% match with sequences patented in US8226943 B2 [1].
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1. Gurney AL, Hoey TC, van der Horst ETH, Sato AK, Liu YC, Bruhns MF, Lewicki JA. (2012)
Antibodies to notch receptors.
Patent number: US8226943 B2. Assignee: Oncomed Pharmaceuticals, Inc.. Priority date: 08/07/2008. Publication date: 24/07/2012.
2. Hu ZI, Bendell JC, Bullock A, LoConte NK, Hatoum H, Ritch P, Hool H, Leach JW, Sanchez J, Sohal DPS et al.. (2019)
A randomized phase II trial of nab-paclitaxel and gemcitabine with tarextumab or placebo in patients with untreated metastatic pancreatic cancer.
Cancer Med, 8 (11): 5148-5157. [PMID:31347292]
3. Smith DC, Chugh R, Patnaik A, Papadopoulos KP, Wang M, Kapoun AM, Xu L, Dupont J, Stagg RJ, Tolcher A. (2019)
A phase 1 dose escalation and expansion study of Tarextumab (OMP-59R5) in patients with solid tumors.
Invest New Drugs, 37 (4): 722-730. [PMID:30591982]