tarextumab   Click here for help

GtoPdb Ligand ID: 8453

Synonyms: OMP-59R5
Compound class: Antibody
Comment: Tarextumab is fully human IgG2 monoclonal antibody targeting Notch receptors 2 and 3.
Peptide sequence information for this antibody is available from its IMGT/mAb-DB record. A BLAST search using the peptide sequence of the variable region of the heavy chain of tarextumab reveals 100% match with sequences patented in US8226943 B2 [1].
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Bioactivity Comments
The binding affinity for anti-Notch2/3 59R1 antibody, an embodiment of patent US8226943 B2 [1] is provided in the table below. It is not clear if this is the antibody clone becoming tarextumab.
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
notch receptor 2 Hs Antibody Binding >10.0 pKd - 1
pKd >10.0 (Kd <1x10-10 M) [1]
notch receptor 3 Hs Antibody Binding 9.9 pKd - 1
pKd 9.9 (Kd 1.2x10-10 M) [1]