Synonyms: 1,1'-diethyl-2,2'-cyanine | D-22 | decynium-22 | Dy22 | GNF-Pf-1919 | GNF-Pf-4440 | NSC-97374 | pseudoisocyanine
Compound class:
Synthetic organic
Comment: Decynium 22 is a potent inhibitor of the plasma membrane monoamine transporter (PMAT aka NET4; SLC29A4) [4]. It is also reported to inhibit the organic action transporter OCT2 (SLC22A2) [2]. Strictly, decynium 22 refers to the iodide salt (PubChem CID 5484462), but we show the parent molecule in this ligand entry.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
|
References |
1. Engel K, Wang J. (2005)
Interaction of organic cations with a newly identified plasma membrane monoamine transporter. Mol Pharmacol, 68 (5): 1397-407. [PMID:16099839] |
2. Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, Baumann C, Lang F, Busch AE, Koepsell H. (1997)
Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol, 16 (7): 871-81. [PMID:9260930] |
3. Wang J. (2016)
The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition. Clin Pharmacol Ther, 100 (5): 489-499. [PMID:27506881] |
4. Xia L, Zhou M, Kalhorn TF, Ho HT, Wang J. (2009)
Podocyte-specific expression of organic cation transporter PMAT: implication in puromycin aminonucleoside nephrotoxicity. Am J Physiol Renal Physiol, 296 (6): F1307-13. [PMID:19357181] |